Systemic lupus erythematosus (SLE) is the most common form of the autoimmune condition lupus, which affects millions of people worldwide. As people with the disease seek to manage their symptoms and improve their quality of life, the relationship between lupus and stress has become increasingly relevant.

People with lupus tend to be sensitive to both physical and emotional stress, which is thought to play a role in symptom flare-ups. Elevated levels of stress may trigger worsened lupus symptoms, which researchers are continuing to evaluate. This connection could have an impact on how clinicians tackle personalized treatment plans for lupus.

Researchers across the world may find this connection an important aspect of their studies, as stress and mental health could be a factor in managing the disease. Read on to learn more about the connection between lupus and stress.

What Is Lupus?

Lupus, a chronic inflammatory autoimmune disease, affects multiple organ systems and presents a wide range of clinical symptoms. The main form of lupus is systemic lupus erythematosus (SLE), which impacts the majority of patients suffering from this condition. 

Current Understanding of Lupus and Its Symptoms

Lupus occurs when the immune system, which usually protects the body from infections and diseases, mistakenly attacks its own tissues, causing inflammation and, in severe cases, tissue damage. The condition is often characterized by fluctuating periods of illness (flares) and wellness (remission).

The range of lupus symptoms can vary greatly and typically affect different body systems, including joints, skin, kidneys, blood cells, brain, heart, and lungs. Common symptoms include fatigue, joint pain, skin rashes, and fever, though their manifestation and severity differ from person to person.

The complex nature of lupus can make a diagnosis challenging, as it often mimics other diseases. Healthcare professionals from various fields, such as rheumatology and immunology, may need to collaborate to come up with an accurate and timely diagnosis of lupus.

The Role of Biosamples in Lupus Research

Researchers often rely on the availability and quality of biosamples to better understand the autoimmune disease and develop effective treatments. Biosamples, such as blood, urine, and saliva, contain valuable information about a person’s health and can provide insight into the disease activity of lupus.

By analyzing biosamples from lupus patients, researchers can identify potential biomarkers, which are substances that indicate the presence, progression, or severity of a disease. These biomarkers can ultimately contribute to more accurate diagnostic tools, better disease monitoring, and novel treatment strategies.

As our knowledge of lupus deepens, the connection between the disease and its relationship with stress becomes increasingly relevant. 

How Does Stress Affect the Immune System?

Stress is a natural response to life’s challenges, but when it becomes persistent or chronic, lupus can have adverse effects on the immune system. The immune system is responsible for protecting the body from infections and diseases, as well as maintaining overall health.

Chronic stress can lead to various physiological changes that weaken the immune system. It suppresses the function of T cells, which are vital for warding off infections and diseases. High stress levels can also contribute to increased blood pressure and other health issues, which can negatively affect the immune system’s ability to function effectively.

Frequent exposure to stress signals the body to produce stress hormones that can suppress the immune system. It has also been found that chronic stress can contribute to inflammation, further suppressing the body’s natural defense mechanisms.

Recent studies have found a higher incidence of autoimmune diseases among individuals previously diagnosed with stress-related disorders. This suggests a possible link between stress and the development or worsening of autoimmune conditions. 

For people who are diagnosed with an autoimmune disease, like lupus, managing stress becomes even more important. Not only does stress negatively affect the immune system’s ability to control inflammation, but it can also increase the risk for mental health issues, which are common among patients with lupus.

Research on the connection between stress, the immune system, and autoimmune diseases is still ongoing. As more studies are conducted, healthcare professionals will be better able to provide guidance on stress management and how it may improve disease progression. 

In the meantime, managing stress through healthy lifestyle choices and self-care practices remains a valuable approach to support both physical and mental well-being.

How Are Stress and Lupus Related?

While physical symptoms are often the primary focus, lupus patients may also experience mental health issues. Many people with lupus often experience mental health challenges, such as depression and anxiety. 

Research suggests that people with lupus have higher rates of anxiety and depression compared to those without the disease. This could be due to multiple factors, such as the emotional toll of living with a chronic illness, the side effects of medications, or the disease process itself affecting the nervous system.

Research Methods for Mental Health and Lupus Research

Studying the connection between mental health and lupus involves various approaches, including clinical trials, population-based studies, and longitudinal research. For example, one study found that psychological stress associated with trauma may increase the odds of women developing lupus. Women with post-traumatic stress disorder (PTSD) were found to be three times more likely to develop lupus than women without trauma. 

Another study found that depression may also increase the risk of developing lupus. The study found that women with depression had a two-fold higher risk of systemic lupus erythematosus than women without depression. 

Alleviating the Effects of Stress on Lupus Flares

Living with lupus can be stressful, and this stress may contribute to the worsening of symptoms. Stress management techniques, such as mindfulness practices, exercise, and counseling, can be beneficial for managing lupus symptoms and improving overall well-being.

Support groups can also be helpful in alleviating stress for people with lupus. By connecting with others who share similar experiences, individuals can find comfort, understanding, and practical advice. 

These supportive communities empower people to openly discuss their concerns and challenges, helping them to feel less isolated and overwhelmed. Support groups may also offer valuable resources and coping strategies, which may help reduce stress.

In addition to individual interventions, healthcare providers can make a difference by acknowledging the relationship between stress and lupus flares. That way, they can tailor treatment plans that address not only physical symptoms but also the mental health of their patients.

Collaborating with Foundations and Organizations

Various stakeholders can work together to improve the quality of life for people living with lupus. For example, lupus foundations, healthcare providers, and research organizations can all play a part in improving lupus treatment and care.

The Lupus Foundation of America and Advancing Research

The Lupus Foundation of America (LFA) is a leading organization in supporting the lupus community. The LFA collaborates with experts to provide clear, easy-to-use resources, educational programs, and services that cater to the needs of people affected by lupus. In addition, LFA supports and funds lupus research, which can help develop more effective therapies and improve the quality of life of patients.

How Healthcare Research Organizations Can Make an Impact

Research organizations can work together with lupus foundations and other healthcare organizations by conducting studies. They can develop protocols to determine how medical care can be more inclusive and effective for people living with lupus. 

Research could also focus on improving communication between patients and their healthcare providers, as well as increasing the coordination of care among specialists, such as rheumatologists and other members of the rheumatology team.

By combining the efforts of all these stakeholders, the lupus community can work towards more effective treatment strategies and comprehensive care. This may then lead to improved well-being and quality of life for people living with lupus. As organizations continue to work together and grow, the future of lupus research and care becomes more promising.

Make Research Breakthroughs With iProcess

Clinical trial lab services can greatly impact the success of research studies. For example, biosample procurement can affect whether researchers produce trustworthy results or face issues with quality, regulations, and timely treatment development. 

By teaming up with iProcess, your research organization can take advantage of a large international network, user-friendly technology, and customized services to fit your specific needs.

Now Offering CLIA Lab Services

iProcess is now offering CLIA lab services to further support research endeavors. Our CLIA-certified laboratories are equipped to meet the highest standards of accuracy, reliability, and efficiency, ensuring that research projects proceed seamlessly. 

With CLIA lab services, iProcess is positioned to assist organizations in advancing research and accelerating the development of groundbreaking therapies. You can trust iProcess to deliver top-notch CLIA lab services that complement an existing suite of customized solutions. We also help you maintain regulatory compliance and quality in all aspects of your research.

Upgrade your research efforts with iProcess as your dependable lab services ally, offering steadfast support for your projects. Get in touch with the dedicated professionals at iProcess to explore the benefits available for your organization.


Programs and Services | Lupus Foundation of America

Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades | PMC

Association of Trauma and Posttraumatic Stress Disorder With Incident Systemic Lupus Erythematosus in a Longitudinal Cohort of Women – Roberts – 2017 – Arthritis & Rheumatology | Wiley Online Library

Depression and anxiety in systemic lupus erythematosus | PMC

Association of Stress-Related Disorders With Subsequent Autoimmune Disease | Psychiatry and Behavioral Health | JAMA

Inflammation: The Common Pathway of Stress-Related Diseases | PMC

Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology | Biomedcentral

Original research: Inflammatory markers in saliva and urine reflect disease activity in patients with systemic lupus erythematosus | PMC

Systemic Lupus Erythematosus (Lupus) Basics: Overview, Symptoms, and Causes | PMC

Lupus: An Overview of the Disease And Management Options | PMC

Systemic Lupus Erythematosus – StatPearls | NCBI Bookshelf